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제목 [Caits Lee] AP Biology - Energy_Metabolism Question
6 Lesson_06_Energy_Metabolism 6
작성자 bbz*** 등록일 2018-04-14 오전 8:15:50
안녕하세요 Caits 선생님. 한국말로 말하는게 서툴러서 영어로 질문하겠습니다.

In the equilibrium section, you had a practice problem about the prevailing reaction if "both Q and S were present in the cell in high concentrations." 

I don't really understand what you mean when you say that the high concentration in Q inhibits O->P. Is it because since Q is in high concentration, reverse reaction is favored and O->P is a forward reaction?

Also, if Q and S inhibit formation of P and R, does that mean that it's completely impossible to convert O to P and R, or that the rate of formation is just slowed down? I don't understand how Q and S inhibit the formation of P and R (respectively).. wouldn't Q and S not be present if the preceding formations P and R are inhibited?

Why exactly do high concentration of products inhibit the preceding formations?

I'd like further explanation on the problem itself, because I'm having trouble understanding the concept in general.

Thank you, 감사합니다. 영어로써서 죄송함니다, 하지만 한국어 쓰는 방법 연습하고 있습니다! 다음에는 도움받아서 한국말로 쓰겠습니다.
첨부파일 ScreenShot2018-04-13at4.15.36PM.png
2018-04-17 오후 12:44:18

안녕하세요 ^^
한국말이 서툴러서 영어로 써도 아무 문제 없습니다. 굳이 한국말로 쓰려고 노력하지 않아도되어요

저 영어 다 알아들어요 ㅎㅎ

I don't really understand what you mean when you say that the high concentration in Q inhibits O->P

: this is what its given on the questions. it says that "Q inhibits the reaction of O to form P"

It might be a form of feedback inhibition, where in the series of reaction 

when an early stage enzyme’s activity ( in this case, enzyme that converts O to P )  is inhibited by the end product ( in this case, Q) . This mechanism allows cells to regulate how much of an enzyme’s end product is produced.

 

 

캡처.PNG

 

The feedback inhibition work like the following picture

 

캡처.PNG

The end product (the yellow square) works as a allosteric inhibitor that blocks the binding of the substrate (the greeb triangle) which will make the substrate accumulate. Since the first reaction is blocked, subsequent reaction would not occur, eventually not producing any end product. As End product decrease, the allostric inhibition will ease ( if it was reversible inhibition)  , then the series of reaction will start again. 

 

Back to the question, 

when  Q and S accumulates, it act as allosteric inhibitor of enzyme that converts O to P , O to R respectively. The accumulated O act as allostric inhibitor of enzyme that converts L to M as indicated in the question. And now, only L to N reaction is possible. So the answer is c. 

 

 

답변이 되었는지요..? ^^ 열공하세용~

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